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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:β-Defensin-4 (human) (trifluoroacetate salt)
CAS:370570-43-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:β-Defensin-4 (human) trifluoroacetate salt
CAS:370570-43-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
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Product Name:β-Defensin-4 (human) (trifluoroacetate salt)
CAS:370570-43-7
Purity:95% Package:100μg
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
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Product Name:β-Defensin-4 (human) (trifluoroacetate salt)
CAS:370570-43-7
Purity:0 Package:100μg/RMB 4810
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| Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
| Products Intro: |
Product Name:β-Defensin-4 (human) (trifluoroacetate salt)
CAS:370570-43-7
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| | -Defensin-4 (human) (trifluoroacetate salt) Basic information |
| | -Defensin-4 (human) (trifluoroacetate salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: 1 mg/ml | | form | A lyophilized powder |
| | -Defensin-4 (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.2 β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.2,5 | | References | 1. Lehrer, R.I. Primate defensins Nat. Rev. Microbiol. 2(9),727-738(2004).
2. García, J.R., Krause, A., Schulz, S., et al. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J. 15(10),1819-1821(2001).
3. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines J. Invest. Dermatol. 127(3),594-604(2007).
4. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells J. Immunol. 184(7),3526-3534(2010).
5. Sharma, H., and Nagaraj, R. Antimicrobial activity of human β-defensin 4 analogs: Insights into the role of disulfide linkages in modulating activity Peptides 38(2),255-265(2012). |
| | -Defensin-4 (human) (trifluoroacetate salt) Preparation Products And Raw materials |
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