| Company Name: |
Shanghai finete Pharmaceutical Co., Ltd.
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| Tel: |
021-021-00000000 18221039705 |
| Email: |
finetechpharm@126.com |
| Products Intro: |
Product Name:Foretinib-Based PROTAC 7
CAS:2230821-68-6
Purity:98% Package:1mg;5mg;
10mg;50mg; Remarks:PROTAC E3 ligase
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| | Foretinib-Based PROTAC 7 Basic information |
| Product Name: | Foretinib-Based PROTAC 7 | | Synonyms: | Foretinib-Based PROTAC 7;1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | | CAS: | 2230821-68-6 | | MF: | C58H65F2N7O11S | | MW: | 1106.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2230821-68-6.mol |  |
| | Foretinib-Based PROTAC 7 Chemical Properties |
| Boiling point | 1226.5±65.0 °C(Predicted) | | density | 1.341±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO|55.31|50| | | pka | 13.14±0.70(Predicted) |
| | Foretinib-Based PROTAC 7 Usage And Synthesis |
| Description | SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells. | | storage | Store at -20°C |
| | Foretinib-Based PROTAC 7 Preparation Products And Raw materials |
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