| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:(2R,6R)-Hydroxynorketamine hydrochloride
CAS:1430202-69-9
Purity:>=98% (HPLC) Package:5MG Remarks:SML1873-5MG
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:(2R,6R)-Hydroxynorketamine hydrochloride >=98% (HPLC)
CAS:1430202-69-9
Purity:NULL Package:25mg;5mg Remarks:NULL
|
| Company Name: |
Zhengzhou Akem Chemical Co., Ltd
|
| Tel: |
13303867194 |
| Email: |
3001317055@qq.com |
| Products Intro: |
Product Name:(2R,6R)-Hydroxynorketamine
CAS:1430202-69-9
Purity:98% Package:1g;5g;10g;25ASSAYS;100g;500g
|
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| | (2R,6R)-Hydroxynorketamine Basic information |
| Product Name: | (2R,6R)-Hydroxynorketamine | | Synonyms: | (2R,6R)-Hydroxynorketamine hydrochloride;(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2R,6R)-Hydroxynorketamine;(2R,6R)-Hydroxynorketamine hydrochloride >=98% (HPLC);(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride;(2S,6R)-2-amino-3-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride | | CAS: | 1430202-69-9 | | MF: | C12H15Cl2NO2 | | MW: | 276.16 | | EINECS: | | | Product Categories: | | | Mol File: | 1430202-69-9.mol |  |
| | (2R,6R)-Hydroxynorketamine Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml | | form | powder | | color | white to beige | | optical activity | [α]/D -95 to -115°, c = 1 in H2O |
| | (2R,6R)-Hydroxynorketamine Usage And Synthesis |
| Uses | cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone Hydrochloride is a metabolite of ketamine and increase AMPA receptor-mediated excitatory post-synaptic potentials in the CA 1 region of hippocampal slices. Anti-depressive effects. | | Biochem/physiol Actions | (2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors. | | storage | Store at RT |
| | (2R,6R)-Hydroxynorketamine Preparation Products And Raw materials |
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