|
|
| Product Name: | dBET6 | | Synonyms: | dBET6;DBET6;DBET-6 ;DBET 6;(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide;dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6;2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide | | CAS: | 1950634-92-0 | | MF: | C42H45ClN8O7S | | MW: | 841.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1950634-92-0.mol |  |
| | dBET6 Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM)
Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM) | | form | A solid | | pka | 10.68±0.40(Predicted) | | color | White to light yellow |
| | dBET6 Usage And Synthesis |
| Description | dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity. | | Definition | ChEBI: DBET6 is an organic molecular entity. | | Biological Activity | dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC. | | target | | Target | Value | BRD4
() | 14 nM |
| | storage | Store at -20°C |
| | dBET6 Preparation Products And Raw materials |
|