(R)-BAY1238097

(R)-BAY1238097 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(R)-BAY1238097
CAS:1564269-85-7
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:(R)-BAY1238097
CAS:1564269-85-7
Purity:98% Package:5mg Remarks:V4201
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:(R)-BAY1238097
CAS:1564269-85-7
Purity:99% Package:$250.9/5mg;$390.9/10mg;$1250.9/50mg;$2100.9/100mg;Bulk package Remarks:99%
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Products Intro: Product Name:R-BAY1238097
CAS:1564269-85-7
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com
Products Intro: Product Name:(R)-BAY1238097
CAS:1564269-85-7
Purity:97.0% Package:5mg
(R)-BAY1238097 Basic information
Product Name:(R)-BAY1238097
Synonyms:(R)-BAY1238097;3H-2,3-Benzodiazepine-3-carboxamide, 4,5-dihydro-7,8-dimethoxy-N,4-dimethyl-1-[4-(4-methyl-1-piperazinyl)phenyl]-, (4R)-;(R)BAY1238097,(R) BAY1238097,(R)-BAY-1238097
CAS:1564269-85-7
MF:C25H33N5O3
MW:451.56
EINECS:
Product Categories:
Mol File:1564269-85-7.mol
(R)-BAY1238097 Structure
(R)-BAY1238097 Chemical Properties
density 1.22±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 150 mg/mL (332.18 mM);Water : < 0.1 mg/mL (insoluble)
form Solid
pka15.43±0.60(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
(R)-BAY1238097 Usage And Synthesis
Description

(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2]. BET[1].

References

[1]. Lejeune, P., et al. (2015) Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Cancer Research, 75(15 Suppl), 884. [2]. Bernasconi E, et al. Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948.

(R)-BAY1238097 Preparation Products And Raw materials
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