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(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one

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(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:BI-2852
CAS:2375482-51-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:BI-2852
CAS:2375482-51-0
Purity:98.98% Package:1mg;118USD|5mg;291USD|10mg;432USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:BI-2852
CAS:2375482-51-0
Purity:98%+ HPLC Package:100mg，200mg，500mg，1g，5g，10g
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Products Intro: Product Name:BI-2852
CAS:2375482-51-0
Purity:98.98% Package:1mg;118USD|5mg;291USD|10mg;432USD
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Products Intro: Product Name:BI-2852
CAS:2375482-51-0
Purity:98% Package:$345.9/5mg;Bulk package Remarks:98%

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one manufacturers

  • BI-2852
  • BI-2852 pictures
  • $118.00 / 1mg
  • 2024-11-19
  • CAS:2375482-51-0
  • Min. Order:
  • Purity: 98.98%
  • Supply Ability: 10g
  • BI-2852
  • BI-2852 pictures
  • $118.00 / 1mg
  • 2024-11-19
  • CAS:2375482-51-0
  • Min. Order:
  • Purity: 98.98%
  • Supply Ability: 10g
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Basic information
Product Name:(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one
Synonyms:(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one;BI-2852;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)-;BI-2852,Ras,inhibit,BI 2852,Inhibitor,BI2852
CAS:2375482-51-0
MF:C31H28N6O2
MW:516.59
EINECS:
Product Categories:
Mol File:2375482-51-0.mol
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Structure
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Chemical Properties
Boiling point 906.5±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:77.5(Max Conc. mg/mL);150.02(Max Conc. mM)
Ethanol:23.0(Max Conc. mg/mL);44.52(Max Conc. mM)
form Solid
pka8.95±0.40(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Usage And Synthesis
Biological ActivityBI-2852 is a switch SI/II pocket KRAS inhibitor with nanomolar affinity through structure-based drug design. It is mechanistically distinct from covalent KRASG12C inhibitors (binding switch II), binding to active KRASG12D 10-fold more strongly than KRAS wt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP and effector interactions with KRAS, resulting in inhibition of downstream signaling and antiproliferative effects in KRAS mutant cells.
in vitro

BI-2852 (Compound 1) (10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC 50 s of 5.8 μM and 6.7 μM in soft agar and low serum conditions in NCI-H358 cells.

target

KRAS(G12C)

450 nM (IC 50 )

KRAS(G12C)

< p> 750 nM (Kd)

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Preparation Products And Raw materials
Tag:(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one(2375482-51-0) Related Product Information
DEMETON S METHYLERGONOVINE