| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Tyk2-IN-7;Tyk2IN7,Tyk2 IN 7,Tyk-2-IN-7
CAS:1609391-90-3
Purity:98% Package:10 mg;100 mg;25 mg;50 mg
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
|
| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:Tyk2-IN-7
CAS:1609391-90-3
Purity:>=99% Package:5mg;200mg;10mg;500mg;50mg;25mg;100mg
|
| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:Tyk2-IN-7
CAS:1609391-90-3
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
|
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| | Tyk2-IN-7 Basic information |
| | Tyk2-IN-7 Chemical Properties |
| storage temp. | 4°C, away from moisture and light | | solubility | Soluble in DMSO | | form | Solid | | color | Off-white to yellow |
| | Tyk2-IN-7 Usage And Synthesis |
| Description | Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].
Tyk2 JH2|0.00053 μM (IC50)|Tyk2 JH2|0.00007 μM (Ki app)
| | References | [1]. Moslin R, et al. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J Med Chem. 2019 Jul 17. |
| | Tyk2-IN-7 Preparation Products And Raw materials |
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