| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Cdc7-IN-1
CAS:1402055-25-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:Cdc7-IN-1
CAS:1402055-25-7
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
|
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| | Cdc7-IN-1 Basic information |
| Product Name: | Cdc7-IN-1 | | Synonyms: | CDC7-IN-1 (COMPOUND 13);Cdc7-IN-1;Cdc7 IN 1,Cdc7IN1,Cdc-7-IN-1;3-Furancarboxylic acid, 2-[(2-chlorophenyl)amino]-4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, ethyl ester | | CAS: | 1402055-25-7 | | MF: | C21H16ClN3O4 | | MW: | 409.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1402055-25-7.mol |  |
| | Cdc7-IN-1 Chemical Properties |
| density | 1.517±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 5.2 mg/mL (12.69 mM) | | pka | 12.52±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Cdc7-IN-1 Usage And Synthesis |
| Description | Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].
IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1] | | References | [1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418. |
| | Cdc7-IN-1 Preparation Products And Raw materials |
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