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| | JKE-1674 Basic information |
| Product Name: | JKE-1674 | | Synonyms: | JKE-1674;ML210,glutathione,Ferroptosis,JKE-1674,peroxidase,inhibit,JKE 1674,Glutathione Peroxidase,rescued,Inhibitor,JKE1674;1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime;(E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one | | CAS: | 2421119-60-8 | | MF: | C20H20Cl2N4O4 | | MW: | 451.3 | | EINECS: | | | Product Categories: | | | Mol File: | 2421119-60-8.mol |  |
| | JKE-1674 Chemical Properties |
| Boiling point | 595.5±60.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 6.67±0.58(Predicted) | | color | Off-white to light yellow |
| | JKE-1674 Usage And Synthesis |
| Biological Activity | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 μM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . | | References | 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020) |
| | JKE-1674 Preparation Products And Raw materials |
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