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Artis Biotech Co. Ltd.
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Product Name:Lamotrigine-d3
CAS:1132746-94-1
Package:1mg;5mg;10mg
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| Company Name: |
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，
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028-83243028 19136088901 |
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Product Name:Lamotrigine-d3 (2,3-dichlorophenyl-d3)
CAS:1132746-94-1
Purity:98 atom % D Package:10mg;100mg;1g
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| Company Name: |
Manhag Testing Technology Co., Ltd
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020-020-3846236 17688849268 |
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Product Name:Lamotrigine-[d3] (2.3-dichlorophenyl-d3)
CAS:1132746-94-1
Purity:99.0 % Package:1mg
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| Company Name: |
Yancheng Tongming Biotechnology Co., Ltd.
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15195160625 |
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2863565288@qq.com |
| Products Intro: |
Product Name:Lamotrigine-d3 (2,3-dichlorophenyl-d3)
CAS:1132746-94-1
Purity:98% HPLC Package:0.005 g In Stock
0.01 g In Stock
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| | LAMOTRIGINE-D3 (2,3-DICHLOROPHENYL-D3) Basic information |
| | LAMOTRIGINE-D3 (2,3-DICHLOROPHENYL-D3) Chemical Properties |
| storage temp. | -20°C | | solubility | Ethanol: 25 mg/ml | | form | A solid | | color | White to off-white |
| | LAMOTRIGINE-D3 (2,3-DICHLOROPHENYL-D3) Usage And Synthesis |
| Biological Activity | Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine by GC- or LC-MS. Lamotrigine is an anticonvulsant.1 It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 μM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA and P-type calcium channel blocker ω-agatoxin IVA .1,2 Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 μmol/kg, respectively).3 It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 μmol/kg).1 Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder. | | References | 1.Drizin, I., Gregg, R.J., Scanio, M.J., et al.Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic painBioorg. Med. Chem.16(12)6379-6386(2008)
2.Stefani, A., Spadoni, F., Siniscalchi, A., et al.Lamotrigine inhibits Ca2+ currents in cortical neurons: Functional implicationsEur. J. Pharmacol.307(1)113-116(1996)
3.Miller, A.A., Wheatley, P., Sawyer, D.A., et al.Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and ratsEpilepsia27(5)483-489(1986) |
| | LAMOTRIGINE-D3 (2,3-DICHLOROPHENYL-D3) Preparation Products And Raw materials |
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