ANTI-CASPASE-12

ANTI-CASPASE-12 Suppliers list

Company Name:	Riedel-de Haen AG
Tel:	800 558-9160
Email:
Products Intro:	Remarks:clone 14F7, purified immunoglobulin, buffered aqueous solution

ANTI-CASPASE-12 Basic information

Product Name:	ANTI-CASPASE-12
Synonyms:	Anti-Caspase-12 (large) antibody produced in rabbit;Anti-Caspase-12 (small) antibody produced in rabbit;ANTI-CASPASE-12;ANTISERUM TO CASPASE-12 (NT);POLYCLONAL ANTIBODY TO CASPASE-12 (NT);MONOCLONAL ANTI-CASPASE 12;Monoclonal Anti-Caspase 12 antibody produced in rat
CAS:
MF:
MW:	0
EINECS:
Product Categories:	1;Alphabetical Index;Antibodies;Antibodies to Caspases;Apoptosis Enzymes;Clone Index;C1 to CACell Signaling Enzymes;Caspase 11, 12, and 13Antibodies for Apoptosis;Caspase 12Antibodies
Mol File:	Mol File

ANTI-CASPASE-12 Chemical Properties

storage temp.	−20°C
form	buffered aqueous solution

Safety Information

MSDS Information

ANTI-CASPASE-12 Usage And Synthesis

Uses	Monoclonal Anti-Caspase 12 has been used in immunoblotting and immunocytochemistry (4% paraformaldehyde-fixed, paraffin-embedded).
General Description	Caspase 12 is a protein that belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The human caspase 12 gene is localized at a single locus within the caspase 1/ICE gene cluster on chromosome 11q22. The functionality is lost in humans and they cannot play a role in Alzheimer′s disease. Caspase-12 is detected in endoplasmic reticulum (ER), plays a role in ER-mediated apoptosis and inflammatory caspase activation pathway.
Biochem/physiol Actions	Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion. Casp12 might stimulate nuclear factor-κB (NF-κB) by directing the post-translational degradation of inhibitor of kappa B (IκBα). Overexpression of caspase 12 induces apoptosis, which is inhibited by the pan caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethyl ketone (z-VAD-FMK).

ANTI-CASPASE-12 Preparation Products And Raw materials

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