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| MMP-8 INHIBITOR I Basic information |
Product Name: | MMP-8 INHIBITOR I | Synonyms: | (3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE];MMP-8 INHIBITOR I;MMP 8-I;3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-;MMP-8 Inhibitor I (Matrix Metalloproteinase-8 Inhibitor I) | CAS: | 236403-25-1 | MF: | C17H18N2O5S | MW: | 362.4 | EINECS: | | Product Categories: | | Mol File: | Mol File | |
| MMP-8 INHIBITOR I Chemical Properties |
storage temp. | -20°C | solubility | Chloroform (Slightly), Methanol (Slightly) | form | Solid | color | Off-White to Light Yellow |
| MMP-8 INHIBITOR I Usage And Synthesis |
Description | MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer. | Uses | MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells. |
| MMP-8 INHIBITOR I Preparation Products And Raw materials |
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