FGI-106
| 中文名称 | FGI-106 |
|---|---|
| 中文同义词 | 化合物 T11281L;化合物FGI-106 TETRAHYDROCHLORIDE;N1,N1'-(3,9-二甲基喹啉并[8,7-H]喹啉-1,7-二基)双(N3,N3-二甲基丙烷-1,3-二胺) 四盐酸盐 |
| 英文名称 | FGI-106 |
| 英文同义词 | FGI-106 tetrahydrochloride;FGI-106 HCl;fever,pathogens,Ebola,Influenza Virus,inhibit,HIV-1,replication,HCV,hemorrhagic,Hepatitis C virus,EBOV,HIV,tetrahydrochloride,FGI106 tetrahydrochloride,Inhibitor,FGI-106 tetrahydrochloride,broad-spectrum,antiviral,Human immunodeficiency virus,lethal,FGI 106 tetrahydrochloride;N,N'-bis(3-(dimethylamino)propyl)-3,9-dimethylquino[8,7-h]quinoline-1,7-diamine tetrahydrochloride;N,N'-bis(3-(dimethylamino)propyl)-3,9-dimethylquino[8,7-h]quinoline-1,7-diamine tetrahydrochloride;N1,N1'-(3,9-Dimethylquinolino[8,7-h]quinoline-1,7-diyl)bis(N3,N3-dimethylpropane-1,3-diamine) tetrahydrochloride |
| CAS号 | 1149348-10-6 |
| 分子式 | C28H39ClN6 |
| 分子量 | 495.11 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1149348-10-6.mol |
| 结构式 |  |
FGI-106 性质
| 熔点 | >280 °C |
|---|---|
| 储存条件 | Store at -20°C |
| 形态 | 固体 |
| 颜色 | 浅棕色至棕色 |
FGI-106 tetrahydrochloride 是一种有效的广谱抑制剂，对多种病毒具有抑制活性。FGI-106 tetrahydrochloride 具有抗埃博拉病毒 (EBOV)，裂谷病毒 (Rift Valley virus) 和登革热病毒 (Dengue Fever virus) 的活性，其 EC50 分别为 100 nM，800 nM 和 400-900 nM。FGI-106 tetrahydrochloride 还分别以 EC50 值为 200 nM 和 150 nM 抑制非失血性发热病毒 HCV 和 HIV-1。
EC50: 100 nM (Ebola virus), 800 nM (Rift Valley virus), 400-900 nM (Dengue Fever virus), 200 nM (HCV) and 150 nM (HIV-1)
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC
90
for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.
FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
| Animal Model: | Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus) |
| Dosage: | 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg |
| Administration: | Intraperitoneal injection; treatments on days 2 and 5 |
| Result: | Decreased mortality from Zaire EBOV in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-124618A | FGI-106 tetrahydrochloride | 1 mg | 1000元 | |
| 2024/11/08 | HY-124618A | FGI-106 FGI-106 tetrahydrochloride | 1149348-10-6 | 5mg | 2500元 |