| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-SENP1
Purity:Prestige Antibody pow Package:100μL Remarks:HPA011765
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| | ANTI-SENP1 Basic information |
| Product Name: | ANTI-SENP1 | | Synonyms: | RABBIT ANTI-HUMAN SENP1;RABBIT ANTI-HUMAN SENTRIN/SUMO-SPECIFIC PROTEASE 1;ANTI-SENP1;ANTI-SENTRIN-SPECIFIC PROTEASES 1;Anti-SENP1 antibody produced in rabbit;Anti-Sentrin/SUMO-specific protease SENP1 antibody produced in rabbit;Anti-Sentrin-specific protease 1 antibody produced in rabbit;Anti-SUMO1/sentrin specific peptidase 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-SENP1 Structure]() |
| | ANTI-SENP1 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-SENP1 Usage And Synthesis |
| Uses | Anti-SENP1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | Biochem/physiol Actions | SENP1 (SUMO1/sentrin specific peptidase 1) is a sentrin/SUMO-specific protease (SENPs) belonging to the de-SUMOylation protease family. It essentially regulates the androgen receptor-dependent transcription and hypoxia signaling. It exerts pro-oncogenic characteristics in various types of malignancies. Studies show that SENP1 is overexpressed in both the cancers, precancerous prostate intraepithelial neoplasia (PIN) lesions and prostate cancer tissues; however, it is correlated with the intensity and recurrence of prostate cancer. SENP1 regulates the expression of two critical bone remodeling proteins, matrix metalloproteinase 2 (MMP2) and MMP9 via HIF1a signaling pathway. Research shows the correlation between SENP1 and the metastasis in prostate cancer, since; it has identifying property as a prognostic marker. |
| | ANTI-SENP1 Preparation Products And Raw materials |
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