11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
中文名称 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE |
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中文同义词 | 5Β-二氢皮质醇 |
英文名称 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE |
英文同义词 | 11,17,21-trihydroxy-,(5beta,11beta)-pregnane-20-dione;11-beta,17,21-trihydroxy-5-beta-pregnane-20-dione;11-beta,17,21-trihydroxy-5-beta-pregnane-3,20-dione;dihydrocortisol;11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE;5-BETA-PREGNAN-11-BETA, 17,21-TRIOL-3,20-DIONE;5BETA-PREGNAN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE;5-BETA-DIHYDROCORTISOL |
CAS号 | 1482-50-4 |
分子式 | C21H32O5 |
分子量 | 364.48 |
EINECS号 | |
相关类别 | Pharmaceuticals, Intermediates & Fine Chemicals, Steroids |
Mol文件 | 1482-50-4.mol |
结构式 |
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 性质
熔点 | >173°C (dec.) |
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沸点 | 544.5±50.0 °C(Predicted) |
密度 | 1.249±0.06 g/cm3(Predicted) |
储存条件 | Refrigerator |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 12.50±0.70(Predicted) |
颜色 | 白色至类白色 |
5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC
50
of 27.59 μM.
5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells.
5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak.
Cell Viability Assay
Cell Line: | MCF-7 and HEK 293 cells |
Concentration: | 10, 20, 40, 60, 80, 100 μM |
Incubation Time: | 48 hours |
Result: |
Inhibited the viability of MCF-7 cells in a dose-dependent manner.
No toxicity in terms of cell viability was observed with HEK293 cell line. |
Apoptosis Analysis
Cell Line: | MCF-7 cells |
Concentration: | 14 μM |
Incubation Time: | 24 hours |
Result: | Induced 35.6% and 2.5% of early and late apoptosis. |
5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits.