Company Name: |
Sigma-Aldrich
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Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:Anti-Calnexin antibody produced in rabbit Purity:IgG fraction of antiserum, buffered aqueous solution Package:.2ML Remarks:C4731-.2ML
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| ANTI-CALNEXIN Basic information |
| ANTI-CALNEXIN Chemical Properties |
storage temp. | −20°C | form | buffered aqueous solution |
| ANTI-CALNEXIN Usage And Synthesis |
Uses | Anti-Calnexin antibody produced in rabbit has been used in:
- western blot analysis
- immunofluorescence
- dual immunofluorescence staining
| General Description | Calnexin contains a long (461 amino acids) N-terminal Ca2+ -binding domain extending into the lumen of the endoplasmic reticulum (ER), a short (22 amino acids) transmembrane segment and an acidic cytosolic domain (96 amino acids). | Biochem/physiol Actions | Calnexin binds newly synthesized glycoproteins and misfolded proteins and is believed to play a critical role in quality control processes during protein synthesis and folding. Calnexin acts as a lectin-like chaperone that binds oligosaccharide residues of newly synthesized N-linked glycoproteins. Calnexin has been shown to be associated with several cell surface proteins, including major histocompatibility complex (MHC) class I heavy chain, T-cell receptor (TCR), and B cell membrane immunoglobulin during translocation through the endoplasmic reticulum (ER). It also forms complexes with other resident ER proteins involved in Ca2+ -dependent retention of proteins. |
| ANTI-CALNEXIN Preparation Products And Raw materials |
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