| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:(2R,3R,4R,5S)-1-(Butyl-d9)-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride
CAS:1883545-57-0
Purity:95% +98%atom%D Package:1mg; Remarks:BD01458536
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Miglustat-d9 HCl
CAS:1883545-57-0
Package:5mg/RMB 16800;1mg/RMB 3620
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| Company Name: |
Shanghai isotope chemical co.,ltd
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| Tel: |
021-021-51600108 13062666369 |
| Email: |
sales@chinaisotope.com |
| Products Intro: |
Product Name:Miglustat-d9 HCl
CAS:1883545-57-0
Purity:1mg Package:1mg Remarks:RMCM32027-1mg
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:N-Butyldeoxynojirimycin-d9 (hydrochloride)
CAS:1883545-57-0
Purity:95% Package:500μg;1mg;5mg
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| Company Name: |
Xi'an Ruipuyuan Biotechnology Co., Ltd
|
| Tel: |
18909235869 18909235890 |
| Email: |
customsynthesis@rpybiotech.com |
| Products Intro: |
Product Name:Miglustat-d9HCl
CAS:1883545-57-0
Purity:96% Package:1mg
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| | [2H9]-N-Butyldeoxynojirimycin Hydrochloride Basic information |
| | [2H9]-N-Butyldeoxynojirimycin Hydrochloride Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: soluble,DMSO: soluble,Methanol: soluble | | form | A solid | | Water Solubility | Water: soluble |
| | [2H9]-N-Butyldeoxynojirimycin Hydrochloride Usage And Synthesis |
| Uses | N-Butyldeoxynojirimycin Hydrochloride-d9 is labelled N-Butyldeoxynojirimycin Hydrochloride (B691000) which is an inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. | | Biological Activity | N-Butyldeoxynojirimycin-d9 (NB-DNJ-d9) is intended for use as an internal standard for the quantification of NB-DNJ by GC- or LC-MS. NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and β-glucosidase 2 (IC50s = 32 and 81 μM, respectively, for the rat recombinant enzymes).1 It also increases the activity of wild-type acid β-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells expressing the human enzymes when used at a concentration of 10 μM.2 NB-DNJ also inhibits HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs; IC50s = 282 and 211 μM, respectively).3 Formulations containing NB-DNJ have been used in the treatment of Gaucher disease, an inborn error of metabolism characterized as a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase. | | References | 1.Lee, J.C., Francis, S., Dutta, D., et al.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidasesJ. Org. Chem.77(7)3082-3098(2012)
2.Alfonso, P., Pampín, S., Estrada, J., et al.Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutationsBlood Cells Mol. Dis.35(2)268-276(2005)
3.Pollock, S., Dwek, R.A., Burton, D.R., et al.N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome deliveryAIDS22(15)1961-1969(2008) |
| | [2H9]-N-Butyldeoxynojirimycin Hydrochloride Preparation Products And Raw materials |
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