| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ATX inhibitor 5
CAS:2402772-45-4
Purity:99.23% Package:1 mg；5 mg；10 mg；25 mg；50 mg；100 mg
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:ATX inhibitor 5
CAS:2402772-45-4
Purity:>=99% Package:10mM*1mLinDMSO;200mg;100mg;10mg;5mg;50mg;25mg;500mg
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| | ATX inhibitor 5 Basic information |
| Product Name: | ATX inhibitor 5 | | Synonyms: | (E)-N'-(4-chlorobenzylidene)-4-((3-(trifluoromethyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carbohydrazide;ATX inhibitor 5 | | CAS: | 2402772-45-4 | | MF: | C22H18ClF3N6O | | MW: | 474.87 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ATX inhibitor 5 Structure]() |
| | ATX inhibitor 5 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (526.46 mM; Need ultrasonic) | | pka | 10.89±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | ATX inhibitor 5 Usage And Synthesis |
| Biological Activity | ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].
ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC)[1].ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β[1].
ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently[1]. | | References | [1]. Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904. |
| | ATX inhibitor 5 Preparation Products And Raw materials |
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