| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:PROTACPARP1degrader
CAS:2369022-68-2
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:PROTAC PARP1 degrader
CAS:2369022-68-2
Package:1mg/RMB 7190
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| | PROTAC PARP1 degrader Basic information |
| Product Name: | PROTAC PARP1 degrader | | Synonyms: | PROTAC PARP1 degrader;2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]-;2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-{1-[14-(2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamido)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}phenyl)-2H-indazole-7-carboxamide | | CAS: | 2369022-68-2 | | MF: | C58H63Cl2N11O10 | | MW: | 1145.09 | | EINECS: | | | Product Categories: | | | Mol File: | 2369022-68-2.mol |  |
| | PROTAC PARP1 degrader Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 14.32±0.46(Predicted) | | color | White to off-white |
| | PROTAC PARP1 degrader Usage And Synthesis |
| Biological Activity | PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM. | | References | [1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372. |
| | PROTAC PARP1 degrader Preparation Products And Raw materials |
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