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3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester

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3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:COR659
CAS:544450-68-2
Purity:99.56% Package:1mg;48USD|2mg;69USD|5mg;118USD
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:COR659
CAS:544450-68-2
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:COR659
CAS:544450-68-2
Purity:99% Package:$300.9/5mg;$500.9/10mg;$950.9/25mg;$1550.9/50mg;$2350.9/100mg;Bulk package Remarks:99%
Company Name: Shanghai Raise Chemical Technology Co.,Ltd  
Tel: 15026594951
Email: rs@raise-chem.com
Products Intro: Product Name:COR659
CAS:544450-68-2
Purity:97% HPLC Package:1g;5g
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Products Intro: Product Name:COR659
CAS:544450-68-2
Purity:98% Package:5mg

3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester manufacturers

  • COR659
  • COR659 pictures
  • $48.00 / 1mg
  • 2024-11-19
  • CAS:544450-68-2
  • Min. Order:
  • Purity: 99.56%
  • Supply Ability: 10g
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Basic information
Product Name:3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
Synonyms:3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester;COR659;Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate;COR 659,Gamma-aminobutyric acid Receptor,sucrose,inhibit,chocolate,γ-Aminobutyric acid Receptor,GABA Receptor,COR-659,Inhibitor,COR659,alcohol
CAS:544450-68-2
MF:C16H16ClNO3S
MW:337.82
EINECS:
Product Categories:
Mol File:544450-68-2.mol
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Structure
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Chemical Properties
storage temp. 4°C, away from moisture and light
solubility DMSO: 33.33 mg/mL (98.66 mM)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Usage And Synthesis
Biological ActivityCOR659 is a potent positive allosteric modulator (PAM) of GABAB. It alleviates drug addiction to alcohol and chocolate in rats.
in vitro

COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA B receptor and an action at the cannabinoid CB1 receptor.

in vivo

COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
It is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.

Animal Model: Male sP and Wistar rats.
Dosage: 0, 2.5, 5 and 10 mg/kg.
Administration: Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
Result: The magnitude of the reducing effect of the compound on number of lever-responses for alcohol averaged approximately 30, 55, and 70%, in com parison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Preparation Products And Raw materials
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