Company Name: |
BOC Sciences
|
Tel: |
|
Email: |
info@bocsci.com |
Products Intro: |
Product Name:AT-121 CAS:2099681-31-7 Purity:≥95% Remarks:T-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). AT-121 can decrease capsaicin-induced thermal allodynia without increasing scratching activity
|
Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:AT-121 CAS:2099681-31-7 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Company Name: |
Guangzhou Younan Technology Co., Ltd
|
Tel: |
020-020-82000279 18988968278 |
Email: |
sales@ubiochem.com |
Products Intro: |
Product Name:AT-121 CAS:2099681-31-7 Purity:98% Package:5mg;10mg;50mg;100mg
|
Company Name: |
TargetMol Chemicals Inc.
|
Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:AT-121 CAS:2099681-31-7 Purity:97.95% Package:1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
|
|
| Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Basic information |
| Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Chemical Properties |
Boiling point | 650.6±65.0 °C(Predicted) | density | 1.25±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Chloroform: 10 mg/ml; DMF: miscible; DMSO: miscible; Ethanol: miscible; Ethanol:PBS (pH 7.2) (1:20): 50μg/ml | form | Liquid | pka | 10.81±0.60(Predicted) | color | Colorless to light yellow |
| Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Usage And Synthesis |
Description | AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively).1 It stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. It lacks reinforcing effects, a marker of abuse potential, and reduces oxycodone, but not food pellet, reinforcement in a drug self-administration assay in rhesus monkeys when administered at doses ranging from 0.3 to 10 μg/kg per injection. AT-121 (0.01 or 0.03 mg/kg) does not induce hyperalgesia, a marker of tolerance development, in rhesus monkeys. | References | 1. Ding, H., Kiguchi, N., Yasuda, D., et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates Sci. Transl. Med. 10(456),eaar3483(2018). |
| Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Preparation Products And Raw materials |
|