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BOC Sciences
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Product Name:AT-121
CAS:2099681-31-7
Purity:≥95% Remarks:T-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). AT-121 can decrease capsaicin-induced thermal allodynia without increasing scratching activity
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:AT-121
CAS:2099681-31-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Guangzhou Younan Technology Co., Ltd
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020-020-82000279 18988968278 |
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sales@ubiochem.com |
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Product Name:AT-121
CAS:2099681-31-7
Purity:98% Package:5mg;10mg;50mg;100mg
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TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:AT-121
CAS:2099681-31-7
Purity:97.95% Package:1 mg；5 mg；10 mg；25 mg；50 mg；100 mg
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| | Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Basic information |
| | Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Chemical Properties |
| Boiling point | 650.6±65.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: 10 mg/ml; DMF: miscible; DMSO: miscible; Ethanol: miscible; Ethanol:PBS (pH 7.2) (1:20): 50μg/ml | | form | Liquid | | pka | 10.81±0.60(Predicted) | | color | Colorless to light yellow |
| | Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Usage And Synthesis |
| Description | AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively).1 It stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. It lacks reinforcing effects, a marker of abuse potential, and reduces oxycodone, but not food pellet, reinforcement in a drug self-administration assay in rhesus monkeys when administered at doses ranging from 0.3 to 10 μg/kg per injection. AT-121 (0.01 or 0.03 mg/kg) does not induce hyperalgesia, a marker of tolerance development, in rhesus monkeys. | | References | 1. Ding, H., Kiguchi, N., Yasuda, D., et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates Sci. Transl. Med. 10(456),eaar3483(2018). |
| | Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- Preparation Products And Raw materials |
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