Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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Tel: |
010-60605840 18892239720 |
Email: |
psaitong@jm-bio.com |
Products Intro: |
Product Name:Thalidomide-NH-PEG4-Ms CAS:2140807-24-3 Purity:95% Package:100mg;250mg;500mg
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Company Name: |
Xi'an Confluore Biological Technology Co., Ltd.
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Tel: |
+86-156-80926068 +86-15680926068 |
Email: |
1924344760@qq.com |
Products Intro: |
Product Name:Pomalidomide-NH-PEG4-Ms CAS:2140807-24-3 Purity:98% HPLC Package:10MG;25MG;50MG;100MG;1G;5G Remarks:For customers outside China,please use the website:www.confluore.com
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Company Name: |
DC Chemicals
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Tel: |
021-58447131 13564518121 |
Email: |
sales@dcchemicals.com |
Products Intro: |
Product Name:Thalidomide-NH-PEG4-Ms CAS:2140807-24-3 Purity:98% HPLC Package:100mg,250mg,1g
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1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- manufacturers
- Pomalidomide-NH-PEG4-Ms
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- $0.00 / 100mg
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2024-04-02
- CAS:2140807-24-3
- Min. Order: 100mg
- Purity: >98.00%
- Supply Ability: 100mg
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| 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Basic information |
Product Name: | 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- | Synonyms: | 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-;Thalidomide-NH-PEG4-Ms;Pomalidomide-NH-PEG4-Ms | CAS: | 2140807-24-3 | MF: | C22H29N3O10S | MW: | 527.54 | EINECS: | | Product Categories: | | Mol File: | 2140807-24-3.mol | ![1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Structure](CAS/20210111/GIF/2140807-24-3.gif) |
| 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties |
Boiling point | 784.6±60.0 °C(Predicted) | density | 1.426±0.06 g/cm3(Predicted) | pka | 10.74±0.40(Predicted) |
| 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis |
Biological Activity | Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1]. | References | [1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186. |
| 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials |
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