化合物AS1810722
| 中文名称 | 化合物AS1810722 |
|---|---|
| 中文同义词 | 化合物AS1810722;4-[4-[[7-[(3,5-二氟苯基)甲基]-7H-吡咯并[2,3-D]嘧啶-2-基]氨基]苯基]-1-哌嗪乙酰胺;2-(4-(4-((7-(3,5-二氟苄基)-7H-吡咯并[2,3-D]嘧啶-2-基)氨基)苯基)哌嗪-1-基)乙酰胺 |
| 英文名称 | 1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]- |
| 英文同义词 | 1-Piperazineacetamide, 4-[4-[[7-[(3,5-difluorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-;AS1810722;AS-1810722,inhibit,CYPs,AS 1810722,Cytochrome P450,eosinophil,allergic,AS1810722,STAT,orally,Inhibitor,asthma,IL-4,infiltration,IFN-γ;2-(4-(4-((7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)acetamide |
| CAS号 | 909561-15-5 |
| 分子式 | C25H25F2N7O |
| 分子量 | 477.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 909561-15-5.mol |
| 结构式 |  |
化合物AS1810722 性质
| 沸点 | 731.4±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：62.5 mg/mL（130.89 mM） |
| 酸度系数(pKa) | 16.30±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 棕转黑 |
AS1810722 是口服有效的 STAT6 抑制剂，IC50 为 1.9 nM。AS1810722 显示出良好的 CYP3A4 抑制作用。AS1810722 具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。
|
STAT6 1.9 nM (IC 50 ) |
CYP3A4
|
AS1810722 (compound 24) inhibits production of IL-4 with an IC
50
of 2.4 nM, but shows no effect on production of IFN-γ.
AS1810722 (compound 24) suppress eosinophil infiltration in the lung in a dose-dependent manner in an antigen-induced mouse asthmatic model.
AS1810722 inhibits in vitro Th2 differentiation with an IC
50
of 2.4 nM without affecting type 1 helper T (Th1) cell differentiation and eosinophil infiltration in an antigen-induced mouse asthmatic model after oral administration.
| Animal Model: | Female Balb/c mice asthmatic model by intraperitoneal injection of OVA-containing aluminum hydroxide gel |
| Dosage: | 0.03-0.3 mg/kg |
| Administration: | Orally; 30 min before, and 24 and 48 h after OVA exposure |
| Result: | Suppressed eosinophil infiltration in the lung in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-134772 | AS1810722 | 1 mg | 1050元 | |
| 2024/08/19 | HY-134772 | 化合物AS1810722 AS1810722 | 909561-15-5 | 5mg | 2700元 |