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pholedrine sulphate

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pholedrine sulphate Basic information
Product Name:pholedrine sulphate
Synonyms:pholedrine sulphate;4-(2-(METHYLAMINO)PROPYL)PHENOL HEMISULFATE
CAS:6114-26-7
MF:C20H32N2O6S
MW:428.54288
EINECS:228-083-0
Product Categories:
Mol File:6114-26-7.mol
pholedrine sulphate Structure
pholedrine sulphate Chemical Properties
Safety Information
ToxicityLD s.c. in rats: 500 mg/kg (Lindner)
MSDS Information
pholedrine sulphate Usage And Synthesis
OriginatorPholedrine Sulfate, ZYF Pharm Chemical
Manufacturing Process100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic FunctionSympathomimetic, Mydriatic, Analeptic, Vasopressor
pholedrine sulphate Preparation Products And Raw materials
Raw materialsHydrogen-->4-Methoxyphenylacetone-->Nickel
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