CDK4/6-IN-6

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
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Products Intro: Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Package:1 mg;10 mg;100 mg;200 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
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Products Intro: Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:0.98 Package:10G:100G
Company Name: Nantong QuanYi Biotechnology Co., Ltd  Gold
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Products Intro: Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:98%+ HPLC Package:10mg,500mg,1g,2g,5g,10g
Company Name: Shanghai Sphchem Co., Ltd.  
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Email: sales@panhongchem.com
Products Intro: Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:98% Package:1g
CDK4/6-IN-6 Basic information
Product Name:CDK4/6-IN-6
Synonyms:CDK4/6-IN-6;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol;PF-07220060;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;CDK4-IN-I (PF-07220060)
CAS:2380321-51-5
MF:C22H27ClFN5O3
MW:463.94
EINECS:
Product Categories:
Mol File:2380321-51-5.mol
CDK4/6-IN-6 Structure
CDK4/6-IN-6 Chemical Properties
Boiling point 687.4±65.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
form Solid
pka13.43±0.29(Predicted)
color White to off-white
Safety Information
MSDS Information
CDK4/6-IN-6 Usage And Synthesis
Biological ActivityCDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].
References[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
CDK4/6-IN-6 Preparation Products And Raw materials
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