| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd Gold
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g
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| Company Name: |
Shanghai Sphchem Co., Ltd.
|
| Tel: |
21-21-56491756 13512199871 |
| Email: |
sales@panhongchem.com |
| Products Intro: |
Product Name:CDK4/6-IN-6
CAS:2380321-51-5
Purity:98% Package:1g
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| | CDK4/6-IN-6 Basic information |
| Product Name: | CDK4/6-IN-6 | | Synonyms: | CDK4/6-IN-6;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol;PF-07220060;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;CDK4-IN-I (PF-07220060) | | CAS: | 2380321-51-5 | | MF: | C22H27ClFN5O3 | | MW: | 463.94 | | EINECS: | | | Product Categories: | | | Mol File: | 2380321-51-5.mol |  |
| | CDK4/6-IN-6 Chemical Properties |
| Boiling point | 687.4±65.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (538.87 mM; Need ultrasonic) | | form | Solid | | pka | 13.43±0.29(Predicted) | | color | White to off-white |
| | CDK4/6-IN-6 Usage And Synthesis |
| Biological Activity | CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1]. | | References | [1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1. |
| | CDK4/6-IN-6 Preparation Products And Raw materials |
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