| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:Thalidomide-O-amido-C8-NH2 hydrochloride
CAS:2415263-07-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| Company Name: |
Xi'an Confluore Biological Technology Co., Ltd.
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| Tel: |
+86-156-80926068 +86-15680926068 |
| Email: |
1924344760@qq.com |
| Products Intro: |
Product Name:Thalidomide-O-amido-C8-NH2 hydrochloride
CAS:2415263-07-7
Purity:98% HPLC Package:10MG;25MG;50MG;100MG;1G;5G Remarks:For customers outside China,please use the website:www.confluore.com
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Thalidomide-O-amido-C8-NH2 hydrochloride manufacturers
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| | Thalidomide-O-amido-C8-NH2 hydrochloride Basic information |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Usage And Synthesis |
| Biological Activity | Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1]. | | storage | Desiccate at RT | | References | [1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials |
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