| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:ELOVL6-IN-1
CAS:1185736-98-4
Purity:98% HPLC LCMS Package:100MG;1G
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ELOVL6-IN-1
CAS:1185736-98-4
Purity:99.54% Package:1mg/RMB 912;5mg/RMB 1790;10mg/RMB 2630
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:ELOVL6-IN-1
CAS:1185736-98-4
Purity:99.00% Package:1mg;5mg;10mg
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| | ELOVL6-IN-1 Basic information |
| Product Name: | ELOVL6-IN-1 | | Synonyms: | ELOVL6-IN-1;ELOVL6IN1,noncompetitive,orally,palmitoyl-CoA,potent,malonyl-CoA,ELOVL-6-IN-1,Inhibitor,selective,ELOVL6 IN 1,inhibit;1H-Indole-2,4-dione, 3-(2,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-3,5,6,7-tetrahydro-5,5-dimethyl-1-phenyl-3-(trifluoromethyl)- | | CAS: | 1185736-98-4 | | MF: | C27H24F3N3O3 | | MW: | 495.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1185736-98-4.mol |  |
| | ELOVL6-IN-1 Chemical Properties |
| Boiling point | 596.8±60.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (100.91 mM; Need ultrasonic) | | pka | -0.43±0.70(Predicted) |
| | ELOVL6-IN-1 Usage And Synthesis |
| Biological Activity | ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].
ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1]. | | References | [1]. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256. |
| | ELOVL6-IN-1 Preparation Products And Raw materials |
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