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Changzhou Chenhong Biotechnology Co., Ltd.
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0519-85788828 13775037613 |
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Product Name:CZC 54252 hydrochloride CAS:1784253-05-9 Purity:99% Package:50mg;100mg;250mg;500mg;1g;5g
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Zhengzhou convergence chemical co., LTD
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0371-0371-55153829 18003835034 |
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Product Name:N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride , CZC-54252 HCl CAS:1784253-05-9 Purity:98% Package:100mg 250mg 500mg 1g 2g 5g 10g 25g 50g 100g 250g 500g 1kg
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Bide Pharmatech Ltd.
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400-1647117 13681763483 |
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product02@bidepharm.com |
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Product Name:N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride CAS:1784253-05-9 Purity:98% Package:100mg;250mg;1g; Remarks:BD01415100
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InvivoChem
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13549236410 |
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sales@invivochem.cn |
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Product Name:CZC54252 HCl CAS:1784253-05-9 Purity:98% HPLC Package:1mg Remarks:V4460
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| Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Basic information |
Product Name: | Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) | Synonyms: | Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1);CZC-54252 HCl;CZC 54252,CZC54252 hydrochloride,injury,inhibit,LRRK2,CZC54252,CZC-54252,neuronal,Leucine-rich repeat kinase 2,neuroprotective,Inhibitor,CZC 54252 hydrochloride,LRRK2-G2019S;N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride , CZC-54252 HCl;N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride | CAS: | 1784253-05-9 | MF: | C22H26Cl2N6O4S | MW: | 541.45 | EINECS: | | Product Categories: | | Mol File: | 1784253-05-9.mol | |
| Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Chemical Properties |
storage temp. | -20° | solubility | Soluble in DMSO (up to 50 mg/ml). | form | solid | color | Off-white | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Usage And Synthesis |
Description | CZC-54252 HCl (1784253-05-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM.1?CZC-54252 attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM).1 The G2019S mutant is a common mutation found in familial Parkinson’s disease patients.2?Cell permeable. | References | 1) Ramsden et al. (2011), Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson’s disease-related toxicity in human neurons; ACS Chem. Biol., 6 102
2) Kramer et al. (2012), Small molecule kinase inhibitors for LRRK2 and their application to Parkinson’s disease models; ACS Chem. Neurosci., 3 151 |
| Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Preparation Products And Raw materials |
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