| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:RTICBM-189
CAS:551909-15-0
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% HPLC LCMS Package:100MG;1G
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| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Basic information |
| Product Name: | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- | | Synonyms: | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;RTICBM-189;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior | | CAS: | 551909-15-0 | | MF: | C15H14Cl2N2O | | MW: | 309.19 | | EINECS: | | | Product Categories: | | | Mol File: | 551909-15-0.mol | ![Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Structure](CAS/20210305/GIF/551909-15-0.gif) |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties |
| Boiling point | 433.1±45.0 °C(Predicted) | | density | 1.330±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (323.43 mM; Need ultrasonic) | | form | Solid | | pka | 13.54±0.46(Predicted) | | color | White to off-white |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Usage And Synthesis |
| Biological Activity | RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1].
RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1]. | | References | [1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432. |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials |
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