Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-

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Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% Package:25mg Remarks:V2596
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Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
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Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% HPLC LCMS Package:100MG;1G
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Basic information
Product Name:Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-
Synonyms:Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;RTICBM-189;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior
CAS:551909-15-0
MF:C15H14Cl2N2O
MW:309.19
EINECS:
Product Categories:
Mol File:551909-15-0.mol
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Structure
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties
Boiling point 433.1±45.0 °C(Predicted)
density 1.330±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (323.43 mM; Need ultrasonic)
form Solid
pka13.54±0.46(Predicted)
color White to off-white
Safety Information
MSDS Information
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Usage And Synthesis
Biological ActivityRTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1].
References[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials
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