| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903 |
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3008007409@qq.com |
| Products Intro: |
Product Name:RTICBM 189
CAS:551909-15-0
Purity:98% Package:5mg Remarks:S89334
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Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- manufacturers
- RTICBM-189
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- $46.00 / 5mg
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2024-11-19
- CAS:551909-15-0
- Min. Order:
- Purity: 98.32%
- Supply Ability: 10g
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| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Basic information |
| Product Name: | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- | | Synonyms: | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;RTICBM-189;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior;RTICBM-189, 10 mM in DMSO | | CAS: | 551909-15-0 | | MF: | C15H14Cl2N2O | | MW: | 309.19 | | EINECS: | | | Product Categories: | | | Mol File: | 551909-15-0.mol | ![Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Structure](CAS/20210305/GIF/551909-15-0.gif) |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties |
| Boiling point | 433.1±45.0 °C(Predicted) | | density | 1.330±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (323.43 mM; Need ultrasonic) | | form | Solid | | pka | 13.54±0.46(Predicted) | | color | White to off-white |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Usage And Synthesis |
| Uses | RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats[1]. | | Biological Activity | RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1].
RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1]. | | in vivo | RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1]. | Animal Model: | Adult male Sprague-Dawley rats weighing 280-300 g[1] | | Dosage: | 10 mg/kg | | Administration: | IP | | Result: | Significantly attenuated drug-induced reinstatement of the cocaine-seeking behavior.
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| Animal Model: | Male Sprague-Dawley rats weighing 258-277 g[1] | | Dosage: | 10 mg/kg (Pharmacokinetic Analysis) | | Administration: | IP | | Result: | Plasma: Cmax (288.4 ng/mL), tmax (0.4 hours), CL_F (240.6 mL/min/kg), AUCinf (715.2 ng/mL × h), half-life t1/2 (9.9 hours).
Brain: Cmax (594.6 ng/mL), tmax (0.4 hours), CL_F (120.7 mL/min/kg), AUCinf (1438.2 ng/mL × h).
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| | IC 50 | CB1: 7.54 (pIC50); hCB1: 5.29 (pIC50); mCB1: 6.25 (pIC50) | | References | [1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432. |
| | Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials |
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