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Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-

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Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98.32% Package:5mg;46USD|10mg;80USD|25mg;173USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:98% Package:25mg Remarks:V2596
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:RTICBM-189
CAS:551909-15-0
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- manufacturers

  • RTICBM-189
  • RTICBM-189 pictures
  • $46.00 / 5mg
  • 2024-11-19
  • CAS:551909-15-0
  • Min. Order:
  • Purity: 98.32%
  • Supply Ability: 10g
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Basic information
Product Name:Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-
Synonyms:Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;RTICBM-189;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior
CAS:551909-15-0
MF:C15H14Cl2N2O
MW:309.19
EINECS:
Product Categories:
Mol File:551909-15-0.mol
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Structure
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties
Boiling point 433.1±45.0 °C(Predicted)
density 1.330±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (323.43 mM; Need ultrasonic)
form Solid
pka13.54±0.46(Predicted)
color White to off-white
Safety Information
MSDS Information
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Usage And Synthesis
Biological ActivityRTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1].
References[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials
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