| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:Caspase-8, human recombinant
Package:100units Remarks: 见优宁维官网
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| Company Name: |
Creative Enzymes
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| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
| Products Intro: |
Product Name:caspase-8
CAS:179241-78-2
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine tagged), buffered aqueous solution, ≥1,000 units/mg protein
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| Company Name: |
Fluorochem Ltd
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| Tel: |
(01457) 868921 (4 lines) |
| Email: |
vernam@fluorochem.co.uk |
| Products Intro: |
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| Product Name: | FLICE | | Synonyms: | MCH5;MCH51;MACH;MACH-1;MACH2;HUMAN CASPASE-8;FLICE;FLICE3 | | CAS: | 179241-78-2 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![FLICE Structure]() |
| | FLICE Chemical Properties |
| storage temp. | −70°C | | form | buffered aqueous solution |
| | FLICE Usage And Synthesis |
| General Description | Human recombinant C?terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213?496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag. | | Biochem/physiol Actions | Caspase 8 is at the top of the hierarchy of the caspase cascade and is considered an initiator caspase. It exists in the cell as an inactive 55?kDa proenzyme. It is converted to the active form, consisting of 18?kDa and 11?kDa subunits, upon its recruitment to the cytoplasmic domain of activated death receptors such as CD95 or TNFR via the adapter protein FADD. The activation of the proenzyme is triggered by the protein′s aggregation, which leads to auto- or transprocessing. Caspase?8 activates downstream caspases (caspases?3, 6, and 7) that cleave key cellular substrates and lead to apoptotic death of the cells. |
| | FLICE Preparation Products And Raw materials |
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