| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Pirepemat fumarate
CAS:2251806-70-7
Purity:95% Package:2mg;5mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Pirepemat fumarate
CAS:2251806-70-7
Package:2mg/RMB 1540;5mg/RMB 2610
|
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| | Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1) Basic information |
| | Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1) Chemical Properties |
| storage temp. | 4°C, away from moisture | | solubility | DMSO : 100 mg/mL (303.67 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1) Usage And Synthesis |
| Biological Activity | Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2].
IRL752 fumarate displays its highest in vitro affinities for 5-HT and NA-related targets[2].
IRL752 (3.7-100 μmol/kg, s.c.) fumarate has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function[2]. | | References | [1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease. [2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419. |
| | Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1) Preparation Products And Raw materials |
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