| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Cu-GTSM
CAS:68341-14-0
Purity:95% Package:1mg;5mg;10mg
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| Company Name: |
RD International Technology Co., Limited
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| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:Cu(II)GTSM
CAS:68341-14-0
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Cu(II)GTSM
CAS:68341-14-0
Purity:详情请点击官网 Package:1 mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Cu-GTSM
CAS:68341-14-0
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| | Cu(II)GTSM Basic information |
| | Cu(II)GTSM Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 20 mg/mL,DMSO: 10 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.16 mg/mL | | form | A solid | | color | Light brown to brown |
| | Cu(II)GTSM Usage And Synthesis |
| Biological Activity | Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM that has diverse biological activities.1,2,3,4 It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC50s = 0.3-0.6 μM for all).1 Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC50s = 0.009 and 0.27 μM, respectively).2 It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 μM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.3 Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer’s disease.4 | | References | 1.Haeili, M., Moore, C., Davis, C.J.C., et al.Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureusAntimicrob Agents Chemother.58(7)3727-3736(2014)
2.Stefani, C., Al-Eisawi, Z., Jansson, P.J., et al.Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilizationJ. Inorg. Biochem.15220-37(2015)
3.Cater, M.A., Pearson, H.B., Wolyniec, K., et al.Increasing intracellular bioavailable copper selectively targets prostate cancer cellsACS Chem. Biol.8(7)1621-1631(2013)
4.Torres, J.B., Andreozzi, E.M., Dunn, J.T., et al.PET imaging of copper trafficking in a mouse model of alzheimer diseaseJ. Nucl. Med.57(1)109-114(2016) |
| | Cu(II)GTSM Preparation Products And Raw materials |
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