| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:YS-370
CAS:2470908-79-1
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
|
| Company Name: |
Absin Bioscience Inc.
|
| Tel: |
021-38015121 15000105423 |
| Email: |
chenjw@absin.cn |
| Products Intro: |
Product Name:YS-370
CAS:2470908-79-1
Purity:98% Package:50mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:YS-370;YS370,YS 370
CAS:2470908-79-1
Purity:98% Package:1 mg;10 mg;100 mg;2 mg;25 mg;5 mg;50 mg
|
| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
|
| Tel: |
0512-65118909 15162312715 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:YS-370
CAS:2470908-79-1
Purity:98%+ Package:1g;10g;100g
|
| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:YS-370
CAS:2470908-79-1
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
|
|
| | Quinazoline, 4-[1-[(2-bromophenyl)methyl]-2-phenyl-1H-indol-3-yl]-7-methoxy-6-[3-(4-morpholinyl)propoxy]- Basic information |
| | Quinazoline, 4-[1-[(2-bromophenyl)methyl]-2-phenyl-1H-indol-3-yl]-7-methoxy-6-[3-(4-morpholinyl)propoxy]- Chemical Properties |
| Boiling point | 784.8±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 8.33 mg/mL (12.55 mM; ultrasonic and warming and heat to 80°C) | | form | Solid | | pka | 7.00±0.10(Predicted) | | color | White to off-white |
| | Quinazoline, 4-[1-[(2-bromophenyl)methyl]-2-phenyl-1H-indol-3-yl]-7-methoxy-6-[3-(4-morpholinyl)propoxy]- Usage And Synthesis |
| Biological Activity | YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1]. | | References | [1]. Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911. |
| | Quinazoline, 4-[1-[(2-bromophenyl)methyl]-2-phenyl-1H-indol-3-yl]-7-methoxy-6-[3-(4-morpholinyl)propoxy]- Preparation Products And Raw materials |
|