尼可曲朵
| 中文名称 | 尼可曲朵 |
|---|---|
| 中文同义词 | 尼可曲朵;尼可曲多;N-(2-(1H-吲哚-3-基)乙基)烟酰胺 |
| 英文名称 | Nicotredole |
| 英文同义词 | Nicotredole;tryptamide;N-(2-(1H-Indol-3-yl)ethyl)nicotinaMide;N-[2-(3-indolyl)ethyl]nicotinamide;3-Pyridinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]-;N-[2-(1H-indol-3-yl)ethyl]pyridine-3-carboxamide;anti-inflammatory,Nicotredole,analgesic,ulcerogenic,inhibit,Inhibitor |
| CAS号 | 29876-14-0 |
| 分子式 | C16H15N3O |
| 分子量 | 265.31 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 29876-14-0.mol |
| 结构式 |  |
尼可曲朵 性质
| 沸点 | 408.53°C (rough estimate) |
|---|---|
| 密度 | 1.0944 (rough estimate) |
| 折射率 | 1.6500 (estimate) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 二甲基亚砜：25 mg/mL（94.23 mM） |
| 形态 | 固体 |
| 颜色 | 浅棕色至棕色 |
Nicotredole inhibits prostaglandin synthetase activity in vitro.
Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema.
Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice.
Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively.
Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively.
Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t
1/2
=4.92-17.5 min) and elimination (t
1/2
=55.72-74.52 min), can reach C
max
(11-13 μg/cm
3
) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm
3
).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-137394 | 尼可曲朵 Nicotredole | 29876-14-0 | 10mM * 1mLin DMSO | 1100元 |
| 2024/04/30 | HY-137394 | 尼可曲朵 Nicotredole | 29876-14-0 | 10mg | 1500元 |