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2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-

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2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Suppliers list
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Products Intro: Product Name:OF-02
CAS:1883431-67-1
Purity:>=98.0% Package:$510.9/5mg;$800.9/10mg;$1600.9/25mg;Bulk package Remarks:98.0%
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Products Intro: Product Name:OF-02
CAS:1883431-67-1
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Products Intro: Product Name:OF-02
CAS:1883431-67-1
Purity:95% Package:1mg;5mg;10mg
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Products Intro: CAS:1883431-67-1
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2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Basic information
Product Name:2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-
Synonyms:2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-;OF-02;3,6-Bis(4-(bis((9Z,12Z)-2-hydroxyoctadeca-9,12-dien-1-yl)amino)butyl)piperazine-2,5-dione
CAS:1883431-67-1
MF:C84H152N4O6
MW:1314.13
EINECS:
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Mol File:1883431-67-1.mol
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Structure
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Chemical Properties
Boiling point 1159.0±65.0 °C(Predicted)
density 0.954±0.06 g/cm3(Predicted)
solubility Ethanol: 10 mg/ml
form Oil
pka12.87±0.60(Predicted)
color Colorless to light yellow
Safety Information
MSDS Information
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Usage And Synthesis
DescriptionOF-02 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 LNPs containing OF-02 localize to the liver after intravenous administration in mice. Intravenous administration of LNPs containing OF-02 and encapsulating human erythropoietin (EPO) mRNA increases serum EPO levels in mice.
UsesOF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
References1. Fenton, O.S., Kauffman, K.J., McClellan, R.L., et al. Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery Adv. Mater. 28(15),2939-2943(2016).
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- Preparation Products And Raw materials
Tag:2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-(1883431-67-1) Related Product Information
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