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9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Suppliers list
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| Company Name: |
Shochem(Shanghai)Co.,Ltd
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| Tel: |
+86-021-51783479 +86-13816874662 |
| Email: |
info@shochem.com |
| Products Intro: |
Product Name:OF-Deg-Lin
CAS:1853202-95-5
Purity:98% Package:1g;100g
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:OF-DEG-LIN
CAS:1853202-95-5
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:OF-Deg-Lin
CAS:1853202-95-5
Purity:98%+ HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，more
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9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester manufacturers
- 50-C2-C18lin2-4tail
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- $0.00 / 1g
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2025-03-31
- CAS:1853202-95-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
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| | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Basic information |
| Product Name: | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester | | Synonyms: | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester;OF-DEG-LIN;50-C2-C18lin2-4tail | | CAS: | 1853202-95-5 | | MF: | C92H160N4O10 | | MW: | 1482.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1853202-95-5.mol | ![9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Structure](CAS/20211123/GIF/1853202-95-5.gif) |
| | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Chemical Properties |
| Boiling point | 1190.6±65.0 °C(Predicted) | | density | 0.968±0.06 g/cm3(Predicted) | | pka | 12.86±0.60(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Usage And Synthesis |
| Uses | OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs). | | in vivo | OF-Deg-Lin (iv, single dose) induces the majority of protein expression in the spleen, labels a certain proportion of B cells in the spleen, while causing minimal translation in other organs in mouse models[2]. | Animal Model: | C57BL/6 mouse models[2] | | Dosage: | 0.75-2.25 mg/kg in form of OF-Deg-Lin mRNA LNPs | | Administration: | iv, single dose | | Result: | Induced 85% of total protein production in the spleen, labeled ca. 7% of the total B cell population in C57BL/6 mice. |
| | References | [1] Rissanou AN, Karatasos K. Effects of the structure of lipid-based agents in their complexation with a single stranded mRNA fragment: a computational study.?Soft Matter. 2022;18(33):6229-6245. DOI:10.1039/d2sm00403h
[2] Fenton OS, et al., Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes. Adv Mater. 2017 Sep;29(33). DOI:10.1002/adma.201606944 |
| | 9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester Preparation Products And Raw materials |
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