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Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:CBP/p300-IN-12
CAS:2738688-57-6
Purity:99% Package:$450.9/1mg;$1280.9/5mg;Bulk package Remarks:99%
INDEX NAME NOT YET ASSIGNED Basic information
Product Name:INDEX NAME NOT YET ASSIGNED
Synonyms:CBP/p300-IN-12
CAS:2738688-57-6
MF:C33H29F4N5O6
MW:667.61
EINECS:
Product Categories:
Mol File:Mol File
INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED Chemical Properties
density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (374.47 mM; Need ultrasonic)
pka13.36±0.70(Predicted)
Safety Information
MSDS Information
INDEX NAME NOT YET ASSIGNED Usage And Synthesis
Biological ActivityCBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450[1]. CBP/p300-IN-12 (Compound 2) shows antiproliferative effect against androgen receptor (AR)-positive LnCaP-FGC cells (EC50 of 87 nM), while displaying significantly less activity in the AR-negative cell line DU-145 (EC50 of 1.37 μM).
References[1]. Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12(5):726-731.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
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