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Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:PROTAC EZH2 Degrader-1
CAS:2641601-67-2
Purity:98+ Package:1g
INDEX NAME NOT YET ASSIGNED Basic information
Product Name:INDEX NAME NOT YET ASSIGNED
Synonyms:PROTAC EZH2 Degrader-1
CAS:2641601-67-2
MF:C54H67N7O8
MW:942.17
EINECS:
Product Categories:
Mol File:2641601-67-2.mol
INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED Chemical Properties
Boiling point 1066.8±65.0 °C(Predicted)
density 1.234±0.06 g/cm3(Predicted)
storage temp. -20°C, away from moisture
solubility DMSO : 160 mg/mL (169.82 mM; Need ultrasonic)
pka10.70±0.40(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
INDEX NAME NOT YET ASSIGNED Usage And Synthesis
Biological ActivityPROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].
References[1]. Juan Xia, et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. J Med Chem. 2022 May 26;65(10):7016-7043.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
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