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CarboMer, Inc.
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858 552 0992 |
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| Products Intro: |
Product Name:Poly(estradiol phosphate)
CAS:28014-46-2
Purity:solid
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| | Polyestradiol Basic information |
| Product Name: | Polyestradiol | | Synonyms: | Polyestradiol;POLYOESTRIOLPHOSPHATE;POLYOESTRADIOLPHOSPHATE;POLYOESTRIOLPHOSPATE;oestradiol phosphate polymer;(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | | CAS: | 28014-46-2 | | MF: | C18H24O8P2X2 | | MW: | 430.328 | | EINECS: | | | Product Categories: | | | Mol File: | 28014-46-2.mol |  |
| | Polyestradiol Chemical Properties |
| | Polyestradiol Usage And Synthesis |
| Chemical Properties | mp 195-202°C | | Originator | Estradurin, Ayerst, US ,1957 | | Manufacturing Process | 3 g of estradiol was dissolved in 75 ml of anhydrous pyridine. The solution was cooled to -10°C, whereupon a solution of 1.1 ml of phosphorus oxychloride in 10 ml of anhydrous pyridine was added with agitation. After the addition, which required 7 minutes, the reaction mixture was kept at -10°C for a further period of 3 hours, and then it was left standing at room temperature for 15 hours. A clear solution thus resulted, to which finely crushed ice was then added. The resulting solution was evaporated in vacuum to dryness. After drying in a vacuum desiccator, 3.8 g of a white powder was obtained. This powder was suspended in 2 ml of pyridine, and 25 ml of 0.5 N sodium hydroxide was added, whereupon a solution was obtained which was then diluted with water to 100 ml.
The solution was then dialyzed through a cellophane membrane against 4 liters of water for 10 hours, with stirring. The dialysis was repeated 2 additional times, with fresh amounts of water. To the dialyzed solution there was added 2 ml of 1 N hydrochloric acid, whereupon polyestradiol phosphatewas precipitated as a white bulky precipitate. This was centrifuged off and washed repeatedly with 0.1 N hydrochloric acid. Thereafter it was dried in a vacuum desiccator. The yield was 3 g of polyestradiol phosphate. The analysis shows 0.65% of water, 1.35% of pyridine and 9.3% of phosphorus (calculated on a dry sample). | | Brand name | Estradurin (Wyeth). | | Therapeutic Function | Estrogen | | Safety Profile | Confirmed carcinogen
producing liver tumors. An experimental
teratogen. A drug used in cancer treatment.
When heated to decomposition it emits
toxic fumes of POx. See also ESTRADIOL,
ESTERS, POLYMERS, and
PHOSPHORIC ACID. |
| | Polyestradiol Preparation Products And Raw materials |
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