Adjudin

Adjudin Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Adjudin
CAS:252025-52-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide
CAS:252025-52-8
Purity:0.99 Package:5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Adjudin;AF-2364
CAS:252025-52-8
Purity:96.51% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Boye Science And Technology Development Co., Ltd.
Tel: 27-81625225 +8615387090420
Email: sumihu@boyechemicals.com
Products Intro: Product Name:1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide
CAS:252025-52-8
Purity:0.98 Package:1KG
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide USP/EP/BP
CAS:252025-52-8
Purity:99.0% min Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

Adjudin manufacturers

Adjudin Basic information
Product Name:Adjudin
Synonyms:1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide;AF-2364;1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide;Adjudin, AF-2364;Adjudin;1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid hydrazide;CS-2018;1-(2,4-Dichloro-benzyl)-1H-indazole-3-carboxylic acid hydrazide
CAS:252025-52-8
MF:C15H12Cl2N4O
MW:335.19
EINECS:
Product Categories:Inhibitors;pharmaceutical intermedaite
Mol File:252025-52-8.mol
Adjudin Structure
Adjudin Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:34.56(Max Conc. mg/mL);103.11(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.5(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.05(Max Conc. mg/mL);0.15(Max Conc. mM)
form A crystalline solid
pka11.88±0.30(Predicted)
color White to off-white
Safety Information
MSDS Information
Adjudin Usage And Synthesis
Biological ActivityAdjudin (AF-2364) is an effective male contraceptive and a potent blocker of Cl? channels. It has anti-inflammatory properties by inhibiting NF-κB p65 nuclear translocation and DNA binding activity and ERK MAPK phosphorylation.
in vitro

Adjudin is a potent blocker of Cl - channels: disrupting Cl - ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro . Adjudin (ADD) is a mitochondria inhibitor. Adjudin is a molecule that mediates adherens junction disruption at the Sertoli-germ cell interface. To investigate the effect of Adjudin on cancer cells, more than ten different types of human or mice cancer cell lines are treated with increasing concentrations of Adjudin and the cell proliferation is measured by the modified MTT assay. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC 50 of Adjudin is determined to be 58.0 μM, 13.8 μM, 72.3 μM and 52.7 μM against SGC -7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, res pectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC 50 of Adjudin in A549 cells and PC3 cells is 63.1 μM and 93.0 μM, respectively. For WI -38 and BPH-1 cells, the IC 50 of Adjudin can be observed at more than 300 μM and 200 μM, respectively, which is about 5 times and 2 times more than that for the cancer cell lines A549 and PC3.

in vivo

To determine whether Adjudin can inhibit lung and prostate cancer growth in vivo, the effect of Adjudin is tested in a subcutaneous model of lung and prostate cancer. Human lung carcinoma cells A549 and prostate carcinoma cells PC3 are injected into athymic nude mice subdermally at the lower back site respectively. Mice are then randomized into two treatment groups with similar mean tumor sizes: Adjudin and vehicle (control). Approximately 2 weeks after tumor inoculation Adjudin is injected intraperitoneally once every three days in lung carcinoma cells and every other day in prostate carcinoma cells at 100 mg/kg. Adjudin treatment can be well tolerated in rodent. And Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P =0.006 in the prostate carcinoma cells PC3).

target
TargetValue
Cl? channel
()
NF-κB
()
ERK
()
Adjudin Preparation Products And Raw materials
Raw materialsMethyl 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylate
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