DMP 777 manufacturers
- DMP 777
-
- $95.00 / 2mg
-
2024-10-24
- CAS:157341-41-8
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | DMP 777 Basic information |
| Product Name: | DMP 777 | | Synonyms: | DMP 777;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;L 694458;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution) | | CAS: | 157341-41-8 | | MF: | C31H40N4O6 | | MW: | 564.67 | | EINECS: | | | Product Categories: | | | Mol File: | 157341-41-8.mol |  |
| | DMP 777 Chemical Properties |
| density | 1.227 | | storage temp. | Store at -20°C | | solubility | DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | | form | Powder | | pka | pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain) |
| | DMP 777 Usage And Synthesis |
| Biological Activity | DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE). | | in vivo | DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice. | | target | Human leukocyte elastase (HLE) |
| | DMP 777 Preparation Products And Raw materials |
|