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N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide

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N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:923509-20-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:VU534
CAS:923509-20-0
Purity:99.22% Package:1mg;36USD|5mg;84USD|10mg;139USD
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ：65489617 15618227136
Email: Sales@ATKchemical.com
Products Intro: Product Name:VU534
CAS:923509-20-0
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Products Intro: Product Name:N-(5,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide
CAS:923509-20-0
Purity:98% Package:10mg;25mg;50mg;100mg;250mg; Remarks:BD02220991
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:VU534
CAS:923509-20-0
Purity:99% Package:1mg;5mg;10mg

N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide manufacturers

  • VU534
  • VU534 pictures
  • $36.00 / 1mg
  • 2024-11-19
  • CAS:923509-20-0
  • Min. Order:
  • Purity: 99.22%
  • Supply Ability: 10g
N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Basic information
Product Name:N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide
Synonyms:N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide;VU534;N-(5,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide
CAS:923509-20-0
MF:C21H22FN3O3S2
MW:447.55
EINECS:
Product Categories:
Mol File:923509-20-0.mol
N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Structure
N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Chemical Properties
density 1.412±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear (Warmed)
form Solid
pka10.26±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Usage And Synthesis
Biological ActivityAllosteric site-targeting, reversible, potent and selective N-Acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) activator.

VU534 is a non-cytotoxic (up to 30 μM in murine RAW264.7 and human HepG2 cultures), reversible, potent and selective N-Acyl-phosphatidylethanolamine-hydrolyzing phospholipase D activator (mouse EC50/Emax = 0.30 μM/2.1-fold, human EC50/Emax = 0.93 μM/1.8-fold, using respective recombinant NAPE-PLD) th at targets an allosteric site distinct from th at of PE, DCA, or LEI-401, showing only weak sEH inhibition (IC50/Emax = 1.2 μM/55%) and little potency toward FAAH. VU534 enhances murine BMDMs efferocytosis (by 1.65-fold with 6h 10 μM pretreatment) by activating cellular NAPE-PLD activity (EC50/Emax = 6.6 μM/1.6-fold in RAW264.7 and 1.5 μM/1.6-fold in HepG2).
N-(5,7-Dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide Preparation Products And Raw materials
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