aspergillimide
| 中文名称 | aspergillimide |
|---|---|
| 中文同义词 | 曲霉酰亚胺 |
| 英文名称 | aspergillimide |
| 英文同义词 | aspergillimide;Spiro[5H,6H-5a,9a-(iminomethano)-1H-cyclopent[f]indolizine-7(8H),3'-pyrrolidine]-2',5',10-trione, tetrahydro-1,1',8,8,11-pentamethyl-, (1R,3'R,5aR,8aR,9aS)-rel-(-)-;(rel)-Asperparaline A |
| CAS号 | 195966-93-9 |
| 分子式 | C20H29N3O3 |
| 分子量 | 359.46256 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 195966-93-9.mol |
| 结构式 |  |
aspergillimide 性质
| 沸点 | 546.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：可溶；乙醇：可溶；甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.68±0.60(Predicted) |
| 颜色 | 白色 |
Asperparaline A (1 μM; 1 min) markedly and reversibly blocks the acetylcholine (Ach; 10 µM)-induced current in the silkworm larval neurons.
Asperparaline A (1-1000 nM; 1 min) differentially blocks the peak and slowly desensitizing currents, with IC
50
s of 20.2 and 39.6 nM, respectively.
Asperparaline A (10 μM; 1 min) reduces the peak current amplitude of the ACh (100 µM)-induced response of α3β4 nAChR by 33.4%, while barely influencing the amplitudes of the responses to ACh of the α4β2 and α7 nAChRs in
X. laevis
oocytes.
Asperparaline A (10 μg/g; p.o.) exhibits paralysis against silk worms within 1 h and lasts for 7 to 10 h.
Asperparaline A (3 μg/g; injection with a micro-syringe) exhibits paralysis activity against silk worms within 20 min and lasts for 4 to 5 h.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-124874 | 曲霉酰亚胺 (rel)-Asperparaline A | 195966-93-9 | 5mg | 8748元 |