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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

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Company Name: Yangzhou Qinyuan Pharmatech Co.,ltd
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Products Intro: Product Name:5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-
CAS:302964-08-5
Purity:98% Package:10g;1.00;USD
Company Name: Huanfu Industrial Co.，（Shanghai）Ltd.
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Products Intro: Product Name:N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS:302964-08-5
Package:25kg Remarks:99%
Company Name: Hebei Chuanghai Biotechnology Co,.LTD
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Products Intro: Product Name:Dasatinib Intermediate
CAS:302964-08-5
Purity:99% Package:1KG;5.00;USD|10KG;3.00;USD|50KG;2.00;USD
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS:302964-08-5
Purity:NLT 98% Package:1G;1KG;100KG
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
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Products Intro: Product Name:N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS:302964-08-5
Purity:99% Package:100g ;1KG ;5KG 25KG

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide manufacturers
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Basic information
Product Name:N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Synonyms:2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-;Dasatinib Intermediate 1;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl;2-[(6-chloro-2-MethylpyriMidin-4-yl)aMino]-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide;N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide;N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino];CAY10697
CAS:302964-08-5
MF:C16H13Cl2N5OS
MW:394.28
EINECS:695-686-7
Product Categories:Dasatinib;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:302964-08-5.mol
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Structure
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemical Properties
Melting point 333-335°C
Boiling point 566.95° C (Predicted)
density 1.516±0.06 g/cm3(Predicted)
refractive index n20D 1.72 (Predicted)
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly)
pka10.92±0.70(Predicted)
form Solid
color Pale Yellow
Water Solubility Slightly soluble in water
InChIInChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
InChIKeyLMXUWARKUIELGT-UHFFFAOYSA-N
SMILESS1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
CAS DataBase Reference302964-08-5(CAS DataBase Reference)
Safety Information
HS Code 2933399990
MSDS Information
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Usage And Synthesis
DescriptionN-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.
Chemical PropertiesPale Yellow Solid
UsesDasatinib intermediate. A protein tyrosine kinase inhibitor.
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Preparation Products And Raw materials
Raw materialsThiourea, N-(6-chloro-2-methyl-4-pyrimidinyl)--->2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide-->4,6-Dichloro-2-methylpyrimidine
Preparation ProductsDasatinib
Tag:N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide(302964-08-5) Related Product Information
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