(E)-位变异烟碱
| 中文名称 | (E)-位变异烟碱 |
|---|---|
| 中文同义词 | (E)-位变异烟碱;化合物 T12738L |
| 英文名称 | rivanicline |
| 英文同义词 | rivanicline;But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-;Unii-6H35lf645a;(E)-Metanicotine;(E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-aMine, RJR 2403;(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine;trans-Metanicotine;RIVANICLINE;METANICOTINE;RJR 2403 |
| CAS号 | 15585-43-0 |
| 分子式 | C10H14N2 |
| 分子量 | 162.23156 |
| EINECS号 | |
| 相关类别 | 神经信号;Nicotine Derivatives |
| Mol文件 | 15585-43-0.mol |
| 结构式 |  |
(E)-位变异烟碱 性质
| 沸点 | 99-101°C/0.4mm Hg |
|---|---|
| 密度 | 0.980 |
| 闪点 | 130℃ |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.03±0.10(Predicted) |
| 稳定性 | 吸湿性 |
Rivanicline (RJR-2403; (E)-Metanicotine) 是神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂，对 α4β2 亚型有高度选择性，Ki 为 26 nM，比对 α7 受体的抑制性高超过1000倍。
用途
An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer鈥檚 type and currently being
investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to periphera
l ganglionic and muscle-type nicotinic acetylcholine receptors.