(E)-位变异烟碱
中文名称 | (E)-位变异烟碱 |
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中文同义词 | (E)-位变异烟碱;化合物 T12738L |
英文名称 | rivanicline |
英文同义词 | rivanicline;But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-;Unii-6H35lf645a;(E)-Metanicotine;(E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-aMine, RJR 2403;(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine;trans-Metanicotine;RIVANICLINE;METANICOTINE;RJR 2403 |
CAS号 | 15585-43-0 |
分子式 | C10H14N2 |
分子量 | 162.23156 |
EINECS号 | |
相关类别 | 神经信号;Nicotine Derivatives |
Mol文件 | 15585-43-0.mol |
结构式 | ![]() |
(E)-位变异烟碱 性质
沸点 | 99-101°C/0.4mm Hg |
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密度 | 0.980 |
闪点 | 130℃ |
储存条件 | 2-8°C(protect from light) |
溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
酸度系数(pKa) | 10.03±0.10(Predicted) |
稳定性 | 吸湿性 |
Rivanicline (RJR-2403; (E)-Metanicotine) 是神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂,对 α4β2 亚型有高度选择性,Ki 为 26 nM,比对 α7 受体的抑制性高超过1000倍。
用途
An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer鈥檚 type and currently being
investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to periphera
l ganglionic and muscle-type nicotinic acetylcholine receptors.