Log in | Join Free | china | japan | germany

(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone

Request For Quotation
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:JAK2-IN-6
CAS:353512-04-6
Purity:99% Package:$50.9/1mg;$110.9/5mg;Bulk package Remarks:99%
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:JAK2-IN-6
CAS:353512-04-6
Purity:98% Package:1g
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Email: market@ubiochem.com
Products Intro: Product Name:JAK2-IN-6
CAS:353512-04-6
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
Company Name: Interbioscreen Ltd.   
Tel: +7 (49) 6524-0091
Email: screen@ibscreen.chg.ru
Products Intro: CAS:353512-04-6
Purity:92% Package:1mg Remarks:C14H10ClN3OS2
Company Name: Specs  
Tel: +31 15 251 8111
Email: info@specs.net
Products Intro:
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Basic information
Product Name:(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone
Synonyms:(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone;Methanone, [4-amino-2-(phenylamino)-5-thiazolyl](5-chloro-2-thienyl)-;JAK2-IN-6
CAS:353512-04-6
MF:C14H10ClN3OS2
MW:335.83
EINECS:
Product Categories:
Mol File:353512-04-6.mol
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Structure
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Chemical Properties
storage temp. Store at -20°C
Safety Information
MSDS Information
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Usage And Synthesis
Biological ActivityJAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells[1]. JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours; PC-9, H1975 and PANC-1 cells) treatment exhibits significantly antiproliferative activity against all of these cancer cell lines, with IC50 values of 18.1 μg/mL, 58.3 μg/mL, 40.6 μg/mL against PC-9, H1975 and PANC-1, respectively[1].JAK2-IN-6 (Compound B2), an intramolecular hydrogen bond is formed, holding the chlorothiophene substituent coplanar with the aminothiazole core. The chlorothiophene moiety is found to be located in the binding pocket adjacent to Val863 and Leu983, and extends towards the Asp994 of activation loop and the Gly993 of glycine-rich loop[1].
References[1]. Ting-Ting Yao, et al. Integration of pharmacophore mapping and molecular docking in sequential virtual screening: towards the discovery of novel JAK2 inhibitors. RSC Adv., 2017, 7, 10353-10360.
(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone Preparation Products And Raw materials
Tag:(4-amino-2-anilino-1,3-thiazol-5-yl)(5-chloro-2-thienyl)methanone(353512-04-6) Related Product Information