5-carboxyamidotryptamine maleate
| 中文名称 | 5-carboxyamidotryptamine maleate |
|---|---|
| 中文同义词 | 5-羧酰胺色胺马来酸盐;化合物 T22520;5-CT MALEATE |
| 英文名称 | 5-carboxyamidotryptamine maleate |
| 英文同义词 | 5-carboxyamidotryptamine maleate;5-CT, AH-21467;5-Carboxamidotryptamine maleate salt hemiethanolate;5 Carboxamidotryptamine maleate,5Carboxamidotryptamine maleate |
| CAS号 | 74885-72-6 |
| 分子式 | C15H17N3O5 |
| 分子量 | 319.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 74885-72-6.mol |
| 结构式 |  |
5-carboxyamidotryptamine maleate 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | H2O：可溶，10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 100 mM in water |
|
5-HT 1A Receptor
|
5-HT 1B Receptor
|
5-HT 1D Receptor
|
5-HT 5 Receptor
|
5-HT 7 Receptor
|
[
3
H]-5-Carboxamidotryptamine (5-CT) binding to 5-HT
1D
sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (K
d
= 0.38 nM) and low non-specific binding.
In bovine substantia nigra, [
3
H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [
3
H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides.
Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone).