BREVETOXIN PBTX-3
| 中文名称 | BREVETOXIN PBTX-3 |
|---|---|
| 中文同义词 | 短裸甲藻毒素3;化合物 T10609 |
| 英文名称 | BREVETOXIN PBTX-3 |
| 英文同义词 | DIHYDROBREVETOXIN B;BREVETOXIN PBTX-3;BREVETOXIN PBTX-3, PTYCHODISCUS BREVIS;PUMILIOTOXIN;brevetoxint17;toxint-17;Brevetoxin B, 42-deoxo-42-hydroxy-;PBTX-3 |
| CAS号 | 85079-48-7 |
| 分子式 | C50H72O14 |
| 分子量 | 897.1 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 85079-48-7.mol |
| 结构式 |  |
BREVETOXIN PBTX-3 性质
| 密度 | 1.190±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20C |
| 溶解度 | DMSO：可溶，乙醇：可溶，甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.78±0.70(Predicted) |
| 颜色 | 白色至米白色 |
IC50: voltage-gated Na + channel
Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .
| Animal Model: | Pregnant CD-1 mice |
| Dosage: | 2.8 μg/kg |
| Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 |
| Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |
安全信息
| 危险品运输编号 | 3172 |
|---|---|
| RTECS号 | XW5885000 |
| 危险等级 | 6.1(a) |
| 包装类别 | I |