4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE
生物活性体内研究 用途与合成方法 MSDS 4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE价格(试剂级) 上下游产品信息
| 中文名称 | 4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE |
|---|---|
| 中文同义词 | 化合物 T23425 |
| 英文名称 | 4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE |
| 英文同义词 | 4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE;TC 2559 DIFUMARATE;TC 2559 (fumarate) |
| CAS号 | 212332-35-9 |
| 分子式 | C20H26N2O9 |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 212332-35-9.mol |
| 结构式 |  |
4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE 性质
| 熔点 | 123-125°C |
|---|---|
| 储存条件 | Desiccate at RT |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 100 mM in water |
TC-2559 difumarate 是 CNS 选择性，具有口服活性的烟碱乙酰胆碱受体 (nAChR) α4β2 亚型的部分激动剂。TC-2559 difumarate 对 α2β4、α4β4 和 α3β4 受体表现出选择性，EC50在 10-30 µM 范围内。
TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice.
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats.
| Animal Model: | Adult male mice (body weight 15-30 g) (formalin test) |
| Dosage: | 1, 3, 10 mg/kg |
| Administration: | I.p. |
| Result: | Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. |
| Animal Model: | Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI)) |
| Dosage: | 0.3, 1, 3 mg/kg |
| Administration: | I.p. |
| Result: | Significantly reversed CCI induced the paw withdrawal threshold decreases. |