MP-412 manufacturers
- AV-412 free base
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- $66.00 / 2mg
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2024-10-28
- CAS:451492-95-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | MP-412 | | Synonyms: | 2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-;AV-412 (free base);N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quin;AV-412;MP-412;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide;AV-412 free base (MP-412 free base) | | CAS: | 451492-95-8 | | MF: | C27H28ClFN6O | | MW: | 507 | | EINECS: | | | Product Categories: | | | Mol File: | 451492-95-8.mol |  |
| | MP-412 Chemical Properties |
| Boiling point | 672.9±55.0 °C(Predicted) | | density | 1.33 | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 50 mg/mL (98.62 mM) | | pka | 11.61±0.43(Predicted) | | form | Powder | | color | White to yellow |
| | MP-412 Usage And Synthesis |
| Uses | AV 412 is used in the synthetic preparation of phenylaminoquinazoline derivatives as inhibitors of tyrosine-specific protein kinase for preparation and/or treatment of cancers, diseases caused by arteriosclerosis, or psoriasis. | | in vivo | In animal studies using cancer xenograft models, AV-412 (30 mg/kg) demonstrates complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively. AV-412 suppresses autophosphorylation of EGFR and ErbB2 at the dose corresponding to its antitumor efficacy. When various dosing schedules are applied, AV-412 shows significant effects with daily and every-other-day schedules, but not with a once-weekly schedule, suggesting that frequent dosing is preferable for this compound. Furthermore, AV-412 shows a significant antitumor effect on the ErbB2-overexpressing breast cancer KPL-4 cell line, which is resistant to gefitinib[1]. | | IC 50 | EGFR: 0.75 nM (IC50); ErbB2: 19 nM (IC50); EGFRL858R: 0.51 nM (IC50); EGFRL858R/T790M: 2.3 nM (IC50); EGFRT790M: 0.79 nM (IC50) |
| | MP-412 Preparation Products And Raw materials |
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